Which medications in the drug class Antifungals are used in the treatment of Pediatric Acute Lymphoblastic Leukemia?

Updated: Jan 03, 2019
  • Author: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Antifungals

These agents may change the permeability of the fungal cell, resulting in a fungicidal effect.

Fluconazole

Fluconazole may be used in patients at high risk (eg, infant ALL) to prevent fungal infections. It is a synthetic triazole that inhibits fungal cell growth by inhibiting CYP-dependent synthesis of ergosterol, a vital component of fungal cell membranes.


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