Which medications are used in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

Updated: Jan 02, 2019
  • Author: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP; Chief Editor: Jennifer Reikes Willert, MD  more...
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Medications used in the treatment of pediatric ALL include the following:

  • Antineoplastics (eg, vincristine, asparaginase Escherichia coli, asparaginase Erwinia chrysanthemi, calaspargase pegol, daunorubicin, doxorubicin, MTX, 6-MP, cytarabine, cyclophosphamide, dasatinib, imatinib)

  • Corticosteroids (eg, prednisone, dexamethasone)

  • Antimicrobials (eg, TMX/SMP, pentamidine)

  • Antifungals (eg, fluconazole)

Treatment of T-cell ALL may benefit from high dose methotrexate and the addition of nelarabine, but clinical trial data regarding these two interventions is still pending. Mature B-cell ALL needs to be treated in the same way as disseminated Burkitt lymphoma, with short-term intensive chemotherapy, including high-dose MTX, cytarabine, and cyclophosphamide over a 6-month period.

Blood transfusions or antibiotics may be required to deal with complications of ALL therapy. Do not administer folate supplementation owing to interactions with MTX.

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