Which medications are used in the treatment of pediatric acute lymphoblastic leukemia (ALL)?

Updated: Jan 03, 2019
  • Author: Vikramjit S Kanwar, MBBS, MBA, MRCP(UK), FAAP; Chief Editor: Jennifer Reikes Willert, MD  more...
  • Print
Answer

Medications used in the treatment of pediatric ALL include the following:

  • Antineoplastics (eg, vincristine, asparaginase Escherichia coli, asparaginase Erwinia chrysanthemi, calaspargase pegol, daunorubicin, doxorubicin, MTX, 6-MP, cytarabine, cyclophosphamide, dasatinib, imatinib)

  • Corticosteroids (eg, prednisone, dexamethasone)

  • Antimicrobials (eg, TMX/SMP, pentamidine)

  • Antifungals (eg, fluconazole)

Treatment of T-cell ALL may benefit from high dose methotrexate and the addition of nelarabine, but clinical trial data regarding these two interventions is still pending. Mature B-cell ALL needs to be treated in the same way as disseminated Burkitt lymphoma, with short-term intensive chemotherapy, including high-dose MTX, cytarabine, and cyclophosphamide over a 6-month period.

Blood transfusions or antibiotics may be required to deal with complications of ALL therapy. Do not administer folate supplementation owing to interactions with MTX.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!