Which medications in the drug class Antineoplastics, Monoclonal Antibody are used in the treatment of Pediatric Neuroblastoma?

Updated: Oct 09, 2017
  • Author: Norman J Lacayo, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

Antineoplastics, Monoclonal Antibody

Monoclonal antibodies that bind to the glycolipid disialoganglioside (GD2), expressed on neuroblastoma cells and on normal cells of neuroectodermal origin, have been shown to produce superior outcomes as part of a multimodality regimen.

Dinutuximab (Unituxin)

Dinutuximab is a chimetic monoclonal antibody that binds to the glycolipid disialoganglioside (GD2). GD2 is a glycolipid expressed on neuroblastoma cells and on normal cells of neuroectodermal origin, including central nervous system and peripheral nerves. Dinutuximab binds to cell surface GD2 and induces lysis of GD2-expressing cells through antibody-dependent cell-mediated cycotoxicity and complement-dependent cytotoxicity.


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