Which medications in the drug class Antifungals are used in the treatment of Pediatric Non-Hodgkin Lymphoma?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

Antifungals

These agents may change the permeability of the fungal cell resulting in a fungicidal effect.

Fluconazole (Diflucan)

Fluconazole is a synthetic oral antifungal agent (a broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation.

Nystatin

Nystatin is a fungicidal and fungistatic antibiotic obtained from Streptomyces noursei. It is effective against candidal organisms. It changes the permeability of the fungal cell membrane after binding to cell membrane sterols, causing cellular contents to leak.


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