Which medications are used in the treatment of pediatric non-Hodgkin lymphoma (NHL)?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

The agents described below are used in combination regimens, and doses are tailored to the histologic subtype of lymphoma and the stage of disease present.

In addition to the use of chemotherapeutic drugs, treatment also includes the employment of several classes of medications to support patients with non-Hodgkin lymphoma undergoing aggressive chemotherapy. These include the following:

  • Laxatives and stool softeners

  • Prophylactic antibiotics

  • Antiemetics

  • Antimucositic agents

  • Histamine (H2) receptor antagonists

  • Contraceptives

Prophylactic antibiotics

These medications include the following:

  • Trimethoprim-sulfamethoxazole (against Pneumocystis jiroveci [formerly, carinii])

  • Fluconazole (against Candida species)

  • Nystatin (against Candida species)

Antiemetics

Antiemetics include the following:

  • Serotonin (5-hydroxytryptamine type 3 [5-HT3]) receptor antagonists (ondansetron, granisetron, dolasetron)

  • Phenothiazine

  • Lorazepam

  • Metoclopramide

  • Dexamethasone

  • Tetrahydrocannabinol

Antimucositic agents

These agents include the following:

  • Saline or bicarbonate rinse

  • Biotene rinse

  • Peridex rinse

  • Glutamine suspension

Histamine (H2) receptor antagonists

Famotidine and ranitidine help to prevent gastritis in patients receiving high-dose corticosteroids.

Contraceptives

Oral or injectable contraceptives can be used to suppress menses in female adolescents at risk for menorrhagia due to thrombocytopenia.


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