How is pediatric small noncleaved cell lymphoma treated?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

Since the mid-1980s, survival rates for patients with Burkitt or Burkittlike lymphomas have increased dramatically. In general terms, the following lessons have been learned:

  • Long-term maintenance chemotherapy appears to have no role; therefore, chemotherapy can be short, with the typical duration being 2-6 cycles, each lasting 3-4 weeks (however, the intensity of treatment is high for most patients, and inpatient treatment is required)

  • When observed, relapses occur early, either during therapy or within 6-12 months of its completion; salvage rates for patients with relapse have been disappointing

  • Even patients with widely disseminated disease (eg, bone marrow involvement) have a long-term survival rate of 90%

  • Involvement of the CNS at diagnosis continues to be an adverse prognostic indicator


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