How is pediatric non-Hodgkin lymphoma (NHL) treated?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Proper care of non-Hodgkin lymphoma requires a referral to a comprehensive tertiary care center. The current intense treatment regimens, particularly those for advanced stages of the disease, necessitate inpatient administration of chemotherapy, as well as aggressive support by a team experienced in the care of children with immunosuppression.

Current treatment regimens for lymphoblastic lymphomas (T cell and B cell) are quite similar to protocols for their leukemic counterparts (T-cell ALL and B-cell ALL). In broad terms, these therapies are longer and less intensive (particularly with respect to the use of alkylating agents) than those for small noncleaved-cell lymphoma or LCL, which use relatively high doses of alkylating agents and antimetabolites.

Current survival rates for patients with advanced disease are 65-75% for T-cell lymphoblastic lymphomas and 80-90% for those with B-cell lymphomas.

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