What is the role of serologic analysis in the workup of pediatric non-Hodgkin lymphoma (NHL)?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Other tests may include serologic analyses for varicella, measles, herpes simplex virus, Epstein-Barr virus, cytomegalovirus (CMV), hepatitis A, hepatitis B, and hepatitis C. Perform these tests to document susceptibility in patients who will be receiving immunosuppressive therapy. In addition, these tests may provide evidence of the cause (eg, Epstein-Barr virus).

Serologic results can help in identifying patients who may benefit from transfusion with CMV-negative blood products, especially if bone marrow transplantation is eventually offered. As noted above, however, this is a marginal/arguable recommendation.

Order these tests to confirm previous exposure to a hepatitis virus before blood transfusions are administered.

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