What is the role of lab tests in the workup of pediatric non-Hodgkin lymphoma (NHL)?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

As previously mentioned, a CBC with differential and a platelet count should be obtained in patients with non-Hodgkin lymphoma to assess for possible involvement of the bone marrow and to determine the patient's transfusion requirements.

Measure the prothrombin time, the activated partial thromboplastin time, fibrinogen, and the D-dimer level if the patient is febrile or if he or she has evidence of sepsis. The purpose is to assess for possible disseminated intravascular coagulation, which may require specific therapy.

Obtain blood and urine cultures if the patient has a fever, especially if it is associated with neutropenia. If indicated, also obtain stool and throat cultures.

Analyze the following to assess the patient's renal and hepatic function and to monitor for possible tumor lysis syndrome:

  • Serum electrolytes

  • Blood urea nitrogen (BUN)

  • Creatinine

  • Uric acid

  • Lactate dehydrogenase – The level of lactate dehydrogenase at diagnosis has had prognostic significance in many analyses of treatment outcomes

  • Bilirubin

  • Albumin

  • Total protein

  • Aspartate aminotransferase

  • Alanine aminotransferase

  • Calcium

  • Magnesium

  • Phosphorus


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