What are the signs and symptoms of large cell pediatric non-Hodgkin lymphoma (NHL)?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Constitutional symptoms are uncommon in non-Hodgkin lymphoma, except in patients with anaplastic large cell lymphoma (LCL). Many of these patients have low-grade fever, malaise, anorexia, and/or weight loss. Because LCLs are biologically disparate, however, these lesions have a varied presentation that may include chest or abdominal complications. In rare cases, an LCL appears as an isolated bone lesion in association with pain, swelling, and a risk of pathologic fracture.

Patients with anaplastic LCLs sometimes present with painful skin lesions, bone lesions, peripheral lymphadenopathy, and hepatosplenomegaly. [45, 46] The painful skin lesions may regress spontaneously. A finding less common than these is testicular, lung, or muscle involvement.

Anaplastic LCLs may also result in an apparent cytokine storm, with fevers, vascular leakage, and pancytopenia.

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