What is the role of immunosuppression in the etiology of pediatric non-Hodgkin lymphoma (NHL)?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Immunosuppressed individuals, such as those with human immunodeficiency virus (HIV) infection or those who have undergone solid organ transplantation or bone marrow transplantation, are at increased risk for developing non-Hodgkin lymphoma, particularly small noncleaved cell lymphomas (SNCCL) and large cell lymphomas (LCLs) of B-cell origin. The Epstein-Barr virus, which causes B-cell proliferation and in vitro immortalization, has been implicated in most of these lymphomas. Primary central nervous system (CNS) lymphoma is more common in these patients than in others.

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