What is the role of immunosuppression in the etiology of pediatric non-Hodgkin lymphoma (NHL)?

Updated: Jun 14, 2018
  • Author: J Martin Johnston, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

Immunosuppressed individuals, such as those with human immunodeficiency virus (HIV) infection or those who have undergone solid organ transplantation or bone marrow transplantation, are at increased risk for developing non-Hodgkin lymphoma, particularly small noncleaved cell lymphomas (SNCCL) and large cell lymphomas (LCLs) of B-cell origin. The Epstein-Barr virus, which causes B-cell proliferation and in vitro immortalization, has been implicated in most of these lymphomas. Primary central nervous system (CNS) lymphoma is more common in these patients than in others.


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