How is cancer treated in patients with Li-Fraumeni syndrome?

Updated: Nov 13, 2018
  • Author: ; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Answer

No clear evidence suggests that individuals with Li-Fraumeni syndrome (LFS) diagnosed with cancers should be treated differently from other patients with cancer through the modalities of chemotherapy or surgery. Radiation therapy should be used with caution owing to concerns about increased risk for radiation-induced second primary tumors in Li-Fraumeni syndrome patients. Specifics of therapy are related to the type of cancer.

Based on expert opinions and limited evidence, the National Comprehensive Cancer Network (NCCN) has provided an algorithm for the testing and management of Li-Fraumeni syndrome in adults.


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