What is the focus of clinical history for the evaluation of Li-Fraumeni syndrome?

Updated: Nov 13, 2018
  • Author: ; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
  • Print
Answer

Patients should be counseled about the signs and symptoms of cancer.  They should be encouraged to report any unusual findings, as these may relate to a cancer presentation.

Because of the significantly increased risk of cancer associated with Li-Fraumeni syndrome (LFS), obtaining a thorough family cancer history over at least 3 generations is very important. The history should screen for all tumor types, with particular attention to soft-tissue sarcomas, osteosarcoma, brain tumors, leukemia, and adrenal cortical carcinoma. Occasionally, family history only becomes positive after several years; therefore, updating the family cancer history in patients with Li-Fraumeni syndrome is important.

Obtaining a thorough family history with particular emphasis on cancer can be tedious, but it is an important part of the evaluation of every child diagnosed with a malignancy.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!