What is the role of biologic-response modifiers in the treatment of pediatric acute myelocytic leukemia (AML)?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Granulocyte colony-stimulating factor (G-CSF) and granulocyte monocyte colony-stimulating factor (GM-CSF) shorten the period of chemotherapy-induced neutropenia. However, their role in the treatment of leukemia has not been definitively established, because no improvement in survival has been demonstrated. Their use is not routinely recommended in patients with acute myeloid leukemia.

The role of synthetic erythropoietin has yet to be elucidated, and its use is not recommended.


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