How is pediatric acute myelocytic leukemia (AML) treated?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. Patients are simultaneously given supportive care until their bone marrow achieves hematologic remission and is again producing normal hematopoietic cells.

The role of surgery is limited.

Be vigilant to recognize associated complications, such as infections, hemorrhage, metabolic complications, or early organ dysfunction.

Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. Some hospitalizations can be lengthy. Numerous changes in antibiotics may be necessary until infections and neutropenia resolve.

After transplantation, most febrile episodes require in-patient treatment and observation until profound neutropenia and clinically significant infection resolves.


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