Which histologic findings are characteristic of pediatric acute myelocytic leukemia (AML)?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Bone marrow examination usually reveals characteristic hyperplastic marrow with monotonous replacement with leukemia cells.

Patients with low blast count t(8;21) can also present a diagnostic challenge, sometimes considered a myelodysplastic syndrome, and often require multiple marrow examinations before the diagnosis of leukemia is confirmed. Other patients with myelodysplasia have less than 20% of blast cells, megaloblastic features, and a decrease in the normal hematopoietic cell population.

Pronounced fibrosis is often observed, particularly in the acute megakaryoblastic subtype (M7).


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