What is the role of cytogenetics in the workup of pediatric acute myelocytic leukemia (AML)?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Analysis of the chromosome changes in the leukemic cell is often performed to confirm the diagnosis and for prognostic purposes. If patients have the 9;22 translocation, this would indicate an underlying chronic myelogenous leukemia that would necessitate treatment with tyrosine kinase inhibitors and possibly stem cell transplantation. FLT3 would likewise be an important prognostic marker.

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