What is the role of blood chemistries and other blood work in the workup of pediatric acute myelocytic leukemia (AML)?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Serum uric acid and lactic dehydrogenase levels are frequently elevated as a consequence of increased cell proliferation and destruction.

Serum muramidase (lysozyme) levels are usually increased in patients with monocytic leukemias.

Other signs of tumor lysis, including hyperkalemia, hypocalcemia, and lactic acidosis, may be present.

Blood and urine cultures should always be obtained in a child with fever and leukemia.

Coagulation tests should also be performed during initial diagnosis to look for evidence of disseminated intravascular coagulation that might suggest APL.


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