What are the CNS complications of pediatric acute myelocytic leukemia (AML)?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Central nervous system (CNS) involvement, with leukemic cell infiltration, hemorrhage, or infection, can cause devastating complications or death.

The risk is particularly high for patients with hyperleukocytosis and white blood cell (WBC) counts of more than 200 X 109/L (>200,000/μL). These patients are at greater risk of intracranial hemorrhage, and their conditions must be treated as true emergencies.

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