Which imaging studies are performed in the workup of pediatric acute myelocytic leukemia (AML)?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Answer

Imaging studies are not required for the diagnosis of AML in children, but the following radiologic studies can be helpful in managing complications that arise:

  • Radiography: Routine CXR to rule out mediastinal masses; abdominal images in patients with abdominal pain and distention to rule out perforation; extremity images in patients to rule out metaphyseal bands at the distal femurs (mostly in pediatric ALL), periosteal new bone formation, focal lytic lesions, or pathologic fractures

  • MRI or CT scanning of the head, spine, or other affected areas: For patients with neurologic symptoms to rule out intracranial hemorrhage or infiltrative disease

  • CT scanning of abdomen or sinuses: For abdominal pain or suspected infection of the large bowel; for early detection of asymptomatic sinusitis as cause of persistent, unexplained fevers

  • Echocardiography: To exclude serious infections that affect heart function; also, perform before chemotherapy and periodically with administration of high cumulative doses of anthracyclines (eg, daunomycin, idarubicin)

  • Radionuclide imaging: To detect occult infection that cultures and other imaging modalities do not reveal (eg, occult osteomyelitis, occult deep-tissue infection)


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