What are the signs and symptoms of pediatric acute myelocytic leukemia (AML) due to infiltrative disease?

Updated: Sep 12, 2017
  • Author: Mark E Weinblatt, MD; Chief Editor: Jennifer Reikes Willert, MD  more...
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Symptoms due to the proliferation and infiltration of the abnormal leukemic cell mass and infiltrative disease include the following:

  • Extramedullary infiltration: Most commonly in the reticuloendothelial system

  • Mediastinal mass: May cause symptoms of respiratory insufficiency or superior vena cava syndrome

  • Abdominal masses: May cause pain or obstruct the GI or urogenital tracts

  • Gingival hyperplasia, CNS infiltration: Often associated with monoblastic leukemia (see the image below)

  • Gingival hyperplasia in a patient with monoblastic Gingival hyperplasia in a patient with monoblastic leukemia.

See Clinical Presentation for more detail.


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