Which medications in the drug class Immunomodulators are used in the treatment of Lymphohistiocytosis (Hemophagocytic Lymphohistiocytosis)?

Updated: Feb 26, 2021
  • Author: Robert A Schwartz, MD, MPH; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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Elevated interferon-gamma (INF-gamma) is thought to be part of the pathogenesis that causes the hyperinflammation associated with HLH. Controlling the inflammation helps maintain organ function while preparing for hematopoietic stem-cell transplant (HSCT).

Emapalumab (Gamifant, emapalumab-lzsg)

Human monoclonal antibody that binds to and neutralizes interferon-gamma (IFN-gamma). It is indicated for primary HLH in adults and children (newborn and older) with refractory, recurrent, or progressive disease or who are intolerant to conventional HLH therapy.

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