What are the less common symptoms of carcinoid tumors?

Updated: Feb 12, 2019
  • Author: Cameron K Tebbi, MD; Chief Editor: Max J Coppes, MD, PhD, MBA  more...
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  • Relatively uncommon complaints include joint pain, arthritis, lacrimation, confusion and changes in mental status, ophthalmologic findings associated with flushing or secondary to vascular occlusion, retroperitoneal fibrosis, obstruction of ureter, intra-abdominal fibrosis, Cushing syndrome and male sexual dysfunction.

  • Skin hyperkeratosis and pigmentation and arthritis are also relatively uncommon.

  • Carcinoid tumors have occurred in association with other familial or genetic disorders, such as multiple endocrine neoplasia type 1 (MEN 1) [54] and Peutz-Jeghers syndrome.

  • Multicentric tumor involving more than one organ (eg, larynx and thyroid) has been reported. [55, 56]

  • A second primary tumor in association GI carcinoids can occur. A case of hepatocellular carcinoma post diagnosis of carcinoid tumor has been reported. [57] These secondary tumors tend to be aggressive. In all cases of carcinoid tumor, care should be given to evaluate and follow patients for possible second malignancies.


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