Which diseases can result in disorders of bone mineralization?

Updated: Jun 19, 2020
  • Author: Horacio B Plotkin, MD, FAAP; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Answer

Answer

Several diseases can result in disorders of bone mineralization in children, including rickets, renal diseases (renal osteodystrophy, Fanconi syndrome), tumor-induced osteomalacia, hypophosphatasia, McCune-Albright syndrome, and osteogenesis imperfecta with mineralization defect (syndrome resembling osteogenesis imperfecta [SROI]).

These conditions may result in failure of osteoid calcification (rickets) in children because of a disruption in the pathway of either vitamin D or phosphate metabolism. Rickets, once thought defeated, is reappearing and remains a major health problem in many developing and developed countries. Types of rickets include the following:

  • Nutritional rickets

  • Congenital rickets

  • Rickets of prematurity

  • Vitamin D resistance (type I and type II)

  • Neoplastic rickets

  • Hypophosphatemic rickets

  • Drug-induced rickets


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