Which medications in the drug class Adrenergic Agonists are used in the treatment of Obesity in Children?

Updated: Feb 20, 2019
  • Author: Steven M Schwarz, MD, FAAP, FACN, AGAF; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Answer

Adrenergic Agonists

Adrenergic agonists are stimulants that release tissue stores of epinephrine, causing subsequent alpha- and/or beta-adrenergic stimulation. These drugs have provided benefits to patients with obesity and are approved in adults for short-term use (8-12 wk).

Caffeine

Caffeine is a natural xanthine derivative that directly stimulates all levels of the central nervous system (CNS), cardiovascular system, and voluntary muscles. This agent increases gastric acid secretion and renal blood flow and also has mild diuretic activity.

Phentermine (Adipex-P)

Phentermine is a sympathomimetic amine that increases the release and reuptake of norepinephrine and dopamine. The anorexiant effect of this agent occurs as result of satiety-center stimulation in the hypothalamic and limbic areas of brain. Phentermine is the pharmacologic component of a comprehensive weight-reduction program (including behavioral modification, caloric restriction, exercise) intended for patients with an initial body mass index (BMI) of 30 or 27 kg/m2 and other risk factors (eg, diabetes, hyperlipidemia, hypertension).

Diethylpropion

Diethylpropion is a sympathomimetic amine that is effective as an adjunct for anoretic therapy of exogenous obesity. The anorexiant effect of this drug occurs as a result of satiety-center stimulation in the hypothalamic and limbic areas of brain. Note that diethylpropion is a controlled substance with high potential for abuse and addiction.


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