Which medications in the drug class Melanocortin Agonists are used in the treatment of Obesity in Children?

Updated: Dec 01, 2020
  • Author: Steven M Schwarz, MD, FAAP, FACN, AGAF; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Melanocortin Agonists

Melanocortin-4 (MC4) receptors in the brain are involved in regulation of hunger, satiety, and energy expenditure. Setmelanotide may reestablished MCR receptor pathway activity in patients with obesity due to rare genetic conditions associated with insufficient activation of the MC4 receptor.

Setmelanotide (Imcivree)

MC4 agonist designed to restore impaired MC4 pathway function caused by genetic variants that occur upstream of the receptor. It is indicated for chronic weight management in patients with obesity owing to proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency in adults and children aged 6 years and older. 

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