Are weight loss drugs effective for the treatment of adolescent obesity?

Updated: Dec 01, 2020
  • Author: Steven M Schwarz, MD, FAAP, FACN, AGAF; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Pediatric experience with the use of weight loss drugs is beginning to emerge. One multicenter, randomized trial of orlistat in obese adolescents demonstrated weight stabilization and reduced body fat in the orlistat group, whereas significant weight gain was observed in patients receiving placebo. [60] However, a second study failed to demonstrate any significant benefit from orlistat treatment. [61] Regarding the use of anorectic agents, a 12-month, randomized placebo-controlled trial of sibutramine in 498 adolescents demonstrated a significant, drug-associated reduction in body mass index (BMI) (sibutramine, -8.2% vs placebo, 0.8%,without any observed cardiodynamic effects. [57]

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