How is childhood obesity associated with significant changes in myocardial geometry and function?

Updated: Feb 20, 2019
  • Author: Steven M Schwarz, MD, FAAP, FACN, AGAF; Chief Editor: Jatinder Bhatia, MBBS, FAAP  more...
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Answer

Mangner et al conducted a study to assess geometric and functional changes of the heart in obese compared with nonobese children and adolescents. The authors found thicker left ventricular (LV) walls and an increased LV mass, as well as impaired measures of systolic function, among the obese children when compared with nonobese children. The authors also reported no difference in ejection fractions between the obese and nonobese children, but the average LV strain, strain rate, and displacement, which are markers of LV longitudinal function assessed by 2D speckle-tracking echocardiography (2D-STE), were significantly impaired among the obese children. The results of this study demonstrate that childhood obesity is associated with significant changes in myocardial geometry and function, indicating an early onset of potentially unfavorable alterations in the myocardium. [29, 30]


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