Which medications in the drug class Calcimimetic Agent are used in the treatment of Chronic Kidney Disease in Children?

Updated: Jul 21, 2020
  • Author: Sanjeev Gulati, MD, MBBS, DNB(Peds), DM, DNB(Neph), FIPN(Australia), FICN, FRCPC(Canada); Chief Editor: Craig B Langman, MD  more...
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Answer

Calcimimetic Agent

Calcimimetic agents reduce parathyroid hormone (PTH) levels. A small clinical trial with cinacalcet by Muscheites et al in children with secondary hyperparathyroidism showed an 80% decrease in serum PTH levels.

Cinacalcet (Sensipar)

Cinacalcet directly lowers intact parathyroid hormone (iPTH) levels by increasing the sensitivity of the calcium-sensing receptor on chief cell of the parathyroid gland to extracellular calcium. This process also results in concomitant serum calcium decrease. Cinacalcet is indicated for secondary hyperparathyroidism in patients with chronic kidney disease on dialysis.


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