Which medications in the drug class Immunosuppressants are used in the treatment of Henoch-Schonlein Purpura (IgA Vasculitis)?

Updated: Oct 28, 2020
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Immunosuppressants

Immunosuppressive agents decrease inflammation by suppressing migration of polymorphonuclear leukocytes (PMNs) and reversing increased capillary permeability.

Cyclosporine (Gengraf, Neoral, Sandimmune)

Cyclosporine is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Beauveria nivea. Chemically, cyclosporine is designated as [R-[R*,R*-(E)]]-cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-α-amino-butyryl-Nmethylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl).

Methylprednisolone (Solu-Medrol, Medrol, A-Methapred, Depo-Medrol)

Methylprednisolone decreases inflammation by suppressing PMN migration and reversing increased capillary permeability.

Prednisone (Rayos)

Prednisone is an immunosuppressant used to treat autoimmune disorders; it may decrease inflammation by reversing increased capillary permeability and suppressing PMN activity. It stabilizes lysosomal membranes and suppresses lymphocyte and antibody production.

Prednisolone (Millipred, Orapred, Orapred ODT, Prelone)

Corticosteroids act as potent inhibitors of inflammation. They may cause profound and varied metabolic effects, particularly in relation to salt, water, and glucose tolerance, in addition to their modification of the immune response of the body.

Cyclophosphamide

Cyclophosphamide

Cyclophosphamide is an alkylating agent that is chemically related to nitrogen mustards. It is a cyclic polypeptide that suppresses some humoral activity. Cyclophosphamide is transformed in the liver to active alkylating metabolites, which interfere with the growth of rapidly proliferating cells. When cyclophosphamide is used in autoimmune diseases, its mechanism of action is thought to involve immunosuppression through destruction of immune cells by DNA cross-linking.


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