Which medications in the drug class Analgesic Agents are used in the treatment of Henoch-Schonlein Purpura (IgA Vasculitis)?

Updated: Oct 28, 2020
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Analgesic Agents

Analgesic agents are most commonly used for the relief of mild-to-moderate pain. Although the effects of NSAIDs in the treatment of pain tend to be patient-specific, ibuprofen usually is the drug of choice for initial therapy; other options include flurbiprofen, ketoprofen, and naproxen. Some analgesics (eg, acetaminophen and ibuprofen) are also effective for treating fever.

Ibuprofen (Advil, Motrin, I-Prin, Ibu-200, Neo-Profen)

Ibuprofen is the drug of choice for treatment of mild-to-moderate pain, if not contraindicated; it is also effective for treating fever. Ibuprofen inhibits inflammatory reactions and pain, probably by decreasing the activity of cyclooxygenase, thereby inhibiting prostaglandin synthesis.

Acetaminophen (FeverAll, Q-Pap, Tylenol, APAP 500, Acephen)

Acetaminophen is effective for treating fever and relieving mild-to-moderate pain. It inhibits the action of endogenous pyrogens on heat-regulating centers; it also reduces fever by a direct action on the hypothalamic heat-regulating centers, thereby, in turn, increasing the dissipation of body heat via sweating and vasodilation.

Flurbiprofen

Flurbiprofen has analgesic, antipyretic, and anti-inflammatory effects. It may inhibit cyclooxygenase, causing inhibition of prostaglandin biosynthesis.

Ketoprofen

Ketoprofen is used for relief of mild-to-moderate pain and inflammation.

Naproxen (Anaprox, Naprelan, Naprosyn, Aleve)

Naproxen is used for relief of mild-to-moderate pain. It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, thereby reducing prostaglandin synthesis.


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