What is the role of plasmapheresis in the treatment of Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Plasmapheresis may be effective in delaying the progression of kidney disease. A case series demonstrated good outcomes in adults with severe IgAV who were treated with plasma exchange in addition to steroids. [123] In an uncontrolled study, Shenoy et al reported that children with severe IgAV and IgA nephropathy recover well if treated with plasmapheresis alone, without the need for immunosuppressive therapy. [124] Plasmapheresis has been useful in treating rapidly progressive IgAV nephritis. [125]

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