Which corticosteroid protocols are used in the treatment of severe Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Faedda reported favorable results from the following protocols in patients with severe IgAV [105] :

  • Induction with 250-750 mg of intravenous (IV) methylprednisolone daily for 3-7 days plus oral (PO) cyclophosphamide 100-200 mg/d
  • Maintenance with prednisone 100-200 mg PO every other day plus cyclophosphamide 100-200 mg/day PO for 30-75 days
  • Tapering of prednisone by approximately 25 mg/month (with the cyclophosphamide dose remaining constant)
  • Discontinuation of treatment after at least 6 months by abruptly stopping cyclophosphamide and tapering prednisone completely

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