What is the specific renal pathology of Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Oct 28, 2020
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

The specific kidney pathology of IgAV includes the following:

  • Diffuse hypercellularity
  • Focal and segmental proliferation
  • Mesangial proliferation
  • Minimal change to severe crescentic glomerulonephritis
  • Segmental sclerosis fibrosis
  • Mononuclear cell infiltration
  • Mesangial, subendothelial, and subepithelial deposits
  • Diffuse glomerular deposits of IgA, C3, fibrin, immunoglobulin G (IgG), properdin, and immunoglobulin M (IgM)
  • IgA deposits in the mesangium

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