Which lab findings predict progression risk in Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Coppo et al reported that when severe proteinuria, hypertension, or crescents are present at onset, the risk of IgAV progression is greater in adults and females and appears linked with increasing mean proteinuria levels during follow-up, more so than in patients with decreased renal function at onset. [92] Factor XIII activity seems to correlate with severity of abdominal manifestations [93] ; thus, measuring such activity helps identify patients with severe gastrointestinal (GI) manifestations who might benefit from substitution therapy. [94, 95]


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