What are the neurological symptoms of Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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IgAV  can be accompanied by neurologic manifestations, particularly headaches. Ozkaya et al reported cerebral vasculitis in a child with IgAV and familial Mediterranean fever. [75] In rare cases, IgAV  can be associated with seizures, paresis, or coma.

Other neurologic manifestations of IgAV include the following:

  • Altered mental status
  • Apathy
  • Hyperactivity
  • Irritability
  • Mood lability
  • Somnolence
  • Seizures (partial, complex partial, generalized, or status epilepticus)
  • Focal deficits (eg, aphasia, ataxia, chorea, cortical blindness, hemiparesis, paraparesis, or quadriparesis)
  • Polyradiculoneuropathies (eg, brachial plexus neuropathy or Guillain-Barré syndrome)
  • Mononeuropathies (eg, of the facial nerve, femoral nerve, peroneal nerve, sciatic nerve, or ulnar nerve)

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