What is the primary cause of mortality in individuals with Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Kidney damage related to IgAV is the primary cause of morbidity and mortality. As many as 15% of patients may have long-term kidney insufficiency, but no more than 1-2% will have ESKD. As many as 20% of children who have IgAV and are treated in specialized centers require hemodialysis. The kidney prognosis appears to be worse in adults than in children (in particular, those aged ≤6 years).


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