How does the prevalence of Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Oct 28, 2020
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

IgAV primarily affects children; it may be seen in adults, but much less frequently. [11, 33] In the United States, the prevalence peaks in children aged 5 years. Approximately 75% of cases occur in children aged 2-11 years; IgAV is rare in infants and young children. Older age at the onset of IgAV is associated with the development of chronic renal disease. [58] AHEI, a related but milder condition, occurs in infants younger than 2 years. [59]

Ghrahani et al conducted a retrospective study in children with IgAV in Hasan Sadikin Hospital from 2006 to 2011 to evaluate renal involvement in children with IgAV. The authors reported that there were 128 patients with an age range from 6 month to 15 years. Peak morbidity was between 5-10 years old. In most patients (71%) purpura was the first symptom. Seventy-one patients (44.5%) had arthritis and 89 patients (69.5%) had abdominal pain, while 28 patients (21.8%) had kidney involvement. GI manifestations tend to occur in patients less than 5 years old, while kidney involvement tends to manifest in those 11-15 years old. [60]

A study by Hennies et al that included data from 202 pediatric patients with IgAV nephritis reported that children older than 10 years of age had more insidious onset of non-nephrotic proteinuria, impaired renal function, longer delay to biopsy, and more chronic histopathological lesions than younger children. [61]  


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