What is the global prevalence of Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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In the United Kingdom, the estimated annual incidence of IgAV is 20.4 cases per 100,000 population. [13] In a Norwegian community hospital, the prevalence of IgAV was 3.3 cases per 100,000 inhabitants. [54]

In a study that examined the kidney biopsy results of 65 children younger than 18 years obtained by the Clinical Hospital in the Croatian region of Dalmatia over a 10-year period (1995-2005), 10.8% of glomerulonephritis cases were due to IgAV. [55]

Nong et al reviewed the records of 107 Taiwanese pediatric patients diagnosed with IgAV between 1991 and 2005 who had a mean age of 6.2 ± 2.5 years (range, 2-13 years); the male-to-female ratio was 1:0.7. [56] The primary symptoms included the following:

  • Rashes (95.3%)
  • GI symptoms (72.0%)
  • Joint involvement (46.7%)
  • Kidney involvement (28.0%)

The most common first manifestations were as follows:

  • Rashes (56.1%)
  • GI symptoms (35.5%)
  • Joint involvement (12.1%)

From January 1983 to June 2004, Suehiro et al followed 4502 patients at the Pediatric Rheumatology clinic in Brazil. [57] A diagnosis of IgAV was made in 203 cases (4.5%); 5 patients (0.1%) had acute hemorrhagic edema of infancy (AHEI). All patients with AHEI were male, and the mean age at onset was 18 months (range, 8-21 months).

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