What causes Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Jan 08, 2021
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

The etiology of IgAV remains to be clearly defined but is thought to be multifactorial, with genetic, environmental, and antigenic components. More than 75% of patients report antecedent upper respiratory tract or GI infection. Multiple bacterial and viral infectious agents have been associated with the development of IgAV, and cases also have been reported after drug ingestions and vaccinations. [44]


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