Which hypercoagulability markers are elevated in Henoch-Schönlein purpura (IgA vasculitis)?

Updated: Oct 28, 2020
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Yilmaz et al examined markers of hypercoagulability in 28 children with IgAV and 79 healthy children, and found that levels of fibrinogen, D-dimer, thrombin-antithrombin (TAT) complex, prothrombin fragment (PF)-1, PF-2, and von Willebrand factor antigen (vWAg) and its activity (RiCof) were significantly higher during the acute phase than during the recovery phase and were significantly higher in patients with IgAV than in control subjects. [31] The severity of disease correlated significantly with TAT, PF-1, PF-2, vWAg, and D-dimer levels. Higher levels of matrix metalloproteinase–9 (MMP-9) in urine and serum appear to correlate with increased nephrologic severity in children with IgAV. Use of TNF-α blockers such as adalimumab may increase the risk of developing IgAV.


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