How is renal glucosuria treated?

Updated: Dec 10, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Benign renal glucosuria is a self-limiting process and requires no special medical care. If other associated findings suggest tubular disorders, then appropriate interventions are required. Selective inhibitors of SGLT2 such as dapagliflozin and canagliflozin are a new family of antidiabetic agents recently approved for lowering of blood sugar levels in patients with type 2 diabetes mellitus. [42] Dapagliflozin which is 1200-fold more selective for SGLT2 than SGLT1, either as monotherapy or in combination with other antidiabetic agents. SGLT2 inhibitors reduce blood glucose levels in patients with type 2 diabetes mellitus by inhibiting the glucose reabsorption pathway which results in glucosuria. Studies have also shown that SGLT2 inhibitors reduce body weight and systolic blood pressure, mainly due to its diuretic effect i.e. osmotic diuresis following loss of glucose but also mild urinary sodium loss. [42, 43, 44, 45]


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