What are the possible complications of familial renal glycosuria (FRG)?

Updated: Dec 10, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

FRG is an entity considered to be a benign condition, more a phenotype than a disease.  Some of the following have been reported with this condition:

  • Polyuria and enuresis and later a mild growth and pubertal maturation
  • Episodic dehydration and ketosis during pregnancy and starvation [24]
  • Presence of several autoantibodies without clinical evidence of autoimmune disease [36]
  • An increased incidence of urinary tract infections [37]
  • Activation of the renin-angiotensin-aldosterone system, secondary to natriuresis and possible extracellular volume depletion
  • Hypercalciuria [38]
  • Selective aminoaciduria [39, 40]

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