Which clinical history findings are characteristic of renal glucosuria?

Updated: Dec 10, 2018
  • Author: Rajendra Bhimma, MBChB, MD, PhD, DCH (SA), FCP(Paeds)(SA), MMed(Natal); Chief Editor: Craig B Langman, MD  more...
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Answer

Medical history offers no clues for either primary or benign renal glucosuria. In cases associated with combined tubular defects or hyperglycemia (ie, diabetes mellitus), history is specific to the disease or syndrome.

Renal glucosuria is first noted on routine urinalysis. In cases of glucosuria associated with tubular disorders, a history of growth failure, polyuria, polydipsia, or dehydration may be noted.

Mutations of the SGLT-2 gene have not been associated with other clinical abnormalities such as hypoglycemia, tendency to develop diabetes mellitus, chronic kidney disease or higher rates of infection, especially urinary tract infections. [15] Age at diagnosis ranges from childhood to adulthood. Polyuria associated with sodium wasting and/or aminoaciduria has been reported when daily urinary excretion of glucose is high. [2, 25] Low levels of glycosylated hemoglobin (HbA1c) and insulin have been reported. [26]


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