What are the possible adverse effects of alkylating agents in the treatment of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Cyclophosphamide (CYP) can cause dose-related infertility (including azoospermia, oligospermia, and amenorrhea), nausea, and hair loss. The risk of infertility rises above a cumulative CYP dose of 200 mg/kg. Hair loss, when it occurs, is usually mild and not cosmetically significant in the doses used for most types of INS.

Alkylating agents can also cause myelosuppression and increased susceptibility to infection. CYP can cause hemorrhagic cystitis and increased incidence of bladder malignancy.


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