What are the possible adverse effects of calcineurin inhibitors (CNIs) in the treatment of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Cyclosporin A (CSA) and tacrolimus (TAC) can cause increased susceptibility to infection, direct nephrotoxicity, hyperkalemia, and hypertension. CSA can also cause hirsutism and gingival hyperplasia, whereas TAC can cause impaired glucose tolerance and overt diabetes.


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