What are the possible adverse effects of corticosteroids in the treatment of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Behavioral changes, increased appetite, and Cushingoid signs (rounded, or "moon," facies) are common during the first 6 weeks of daily therapy but typically begin to subside during the alternate-day maintenance therapy period and, if steroids are successfully discontinued, usually disappear completely within 3-6 months

If longer periods of corticosteroid therapy are required, the risk of complications increases. Complications of long-term steroid therapy may include the following:

Nutritional counseling and an exercise regimen may help to limit weight gain during steroid therapy. Consideration should be given to monitoring of bone density by dual energy X-ray absorptiometry (DEXA) in patients who are receiving long-term corticosteroid therapy.


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