What is the role of galactose in the treatment of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Some patients with FSGS have an incompletely characterized circulating permeability factor (FSPF) that has been associated with recurrence of FSGS after kidney transplantation. Galactose has a high affinity for FSPF. An adult patient with FSPF-positive FSGS who was treatment-resistant was given galactose (10 g orally twice daily). [93] He achieved complete remission of proteinuria within 7 months and, 2 years later, remained in complete remission (on a higher dose of 15 g orally twice daily).

In one small study, 7 children with SRNS and positive FSPF activity were treated with oral galactose (0.2 g/kg twice daily) for 16 weeks. Despite a decrease in FSPF, no reduction in proteinuria was demonstrated. [94]

Further studies are needed before the routine use of galactose can be recommended, and its safety and efficacy in children are unknown.


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