What is the role of plasmapheresis in the treatment of pediatric nephrotic syndrome?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Because of the evidence of immunologic mechanisms and presumed circulating factors in the pathophysiology of nephrotic syndrome, plasmapheresis has been attempted in patients with treatment-resistant FSGS and SRNS. To date, a few case reports and small series have shown some efficacy in reducing proteinuria in patients with FSGS or SRNS treated with plasmapheresis or immunoadsorption. [91]

Routine use of plasmapheresis or immunoadsorption in SRNS and FSGS cannot be recommended at this time. However, evidence suggests that plasmapheresis might be effective in treating recurrence of proteinuria in patients with FSGS who have received a kidney transplant. [92]

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