What is the role of levamisole in the treatment of frequently relapsing nephrotic syndrome (FRNS)?

Updated: Mar 04, 2020
  • Author: Jerome C Lane, MD; Chief Editor: Craig B Langman, MD  more...
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Answer

Levamisole is an anthelmintic drug that has immune-modulating effects and can be effective in reducing the relapse rate in FRNS. However, it is unavailable in the United States. Adverse effects include leukopenia, hepatic dysfunction, agranulocytosis, vasculitis, and encephalopathy. Levamisole is prescribed at a dose of 2.5 mg/kg given on alternate days. [41]


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